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• Brun V, Bastian H, Neveu V, Foussat A.
Clinical grade production of IL-10 producing regulatory Tr1 lymphocytes
for cell therapy of chronic inflammatory diseases.

Int Immunopharmacol. 2009 May;9(5):609-13

• Cottrez F, Groux H.
Specialization in tolerance: innate CD(4+)CD(25+) versus acquired TR1
and TH3 regulatory T cells.

Transplantation. 2004 Jan 15;77(1 Suppl):S12-5.

• Foussat A., Cottrez F., Brun V., Fournier N., Breittmayer JP,. Groux H.
A comparative study between T regulatory type 1 and CD4+CD25+ T cells
in the control of inflammation
.
J Immunol. 2003 Nov 15;171(10):5018-26

• Mallat Z, Gojova A, Brun V, Esposito B, Fournier N, Cottrez F, Tedgui A, Groux H.
Induction of a regulatory T cell type 1 response reduces the development of
atherosclerosis in apolipoprotein E-knockout mice.

Circulation. 2003 Sep 9;108(10):1232-7.

• Wakkach A, Cottrez F, Groux H.
Differentiation of regulatory T cells 1 is induced by CD2 costimulation.

J Immunol. 2001 Sep 15;167(6):3107-13.


• Cottrez F, Hurst SD, Coffman RL, Groux H.
T regulatory cells 1 inhibit a Th2-specific response in vivo.

J Immunol. 2000 Nov 1;165(9):4848-53.

• Groux H, O'Garra A, Bigler M, Rouleau M, Antonenko S, de Vries JE, Roncarolo MG.
A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.

Nature. 1997 Oct 16;389(6652):737-42.

 
Relevant Publications

• Rubtsov YP, Rasmussen JP, Chi EY, Fontenot J, Castelli L, Ye X, Treuting P,
Siewe L, Roers A, Henderson WR Jr, Muller W, Rudensky AY.
Regulatory T cell-derived interleukin-10 limits inflammation
at environmental interfaces.

Immunity. 2008 Apr;28(4):546-58.

• Wu K, Bi Y, Sun K, Wang C.
IL-10-producing type 1 regulatory T cells and allergy.
Cell Mol Immunol. 2007 Aug;4(4):269-75.

• Roncarolo MG, Gregori S, Battaglia M, Bacchetta R, Fleischhauer K, Levings MK.
Interleukin-10-secreting type 1 regulatory T cells
in rodents and humans.

Immunol Rev. 2006 Aug;212:28-50.

• Battaglia M, Gregori S, Bacchetta R, Roncarolo MG.
Tr1 cells: from discovery to their clinical application.
Semin Immunol. 2006 Apr;18(2):120-7.

• Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, Thunberg S,
Deniz G, Valenta R, Fiebig H, Kegel C, Disch R, Schmidt-Weber CB, Blaser K, Akdis CA.
Immune responses in healthy and allergic individuals are characterized
by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells.

J Exp Med. 2004 Jun 7;199(11):1567-75.

• Maurer M, Seidel-Guyenot W, Metz M, Knop J, Steinbrink K.
Critical role of IL-10 in the induction of low zone tolerance
to contact allergens.

J Clin Invest. 2003 Aug;112(3):432-9.

• Cong Y, Weaver CT, Lazenby A, Elson CO.
Bacterial-reactive T regulatory cells inhibit pathogenic
immune responses to the enteric flora.

J Immunol. 2002 Dec 1;169(11):6112-9

• Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF,
de Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O'Garra A.

In vitro generation of interleukin 10-producing regulatory CD4(+) T cells
is induced by immunosuppressive drugs and inhibited by T helper type 1
(Th1)- and Th2-inducing cytokines.

J Exp Med. 2002 Mar 4;195(5):603-16.

• Rennick D, Davidson N, Berg D.
Interleukin-10 gene knock-out mice: a model of
chronic inflammation.

Clin Immunol Immunopathol. 1995 Sep;76

 



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